Michael R Zile Selected Research

Cardiac Arrhythmias (Arrythmia)

1/2022	Effect of sacubitril/valsartan on investigator-reported ventricular arrhythmias in PARADIGM-HF.
12/2005	A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: rationale and design of the evaluation of MCC-135 for left ventricular salvage in acute MI (EVOLVE) study.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Michael R Zile Research Topics

Disease

183	Heart Failure 04/2024 - 01/2003
16	Fibrosis (Cirrhosis) 05/2024 - 06/2007
16	Cardiomyopathies (Cardiomyopathy) 04/2024 - 06/2012
16	Myocardial Infarction 01/2023 - 01/2003
15	Hypertension (High Blood Pressure) 01/2023 - 05/2006
15	Hypertrophy 01/2016 - 09/2003
13	Atrial Fibrillation 01/2023 - 07/2014
10	Heart Diseases (Heart Disease) 10/2023 - 05/2006
9	Diastolic Heart Failure 06/2015 - 04/2005
8	Stroke (Strokes) 01/2023 - 03/2012
8	Sudden Death 01/2022 - 09/2011
7	Cardiomegaly (Heart Hypertrophy) 01/2016 - 01/2008
6	Hypotension (Low Blood Pressure) 10/2020 - 09/2014
5	Left Ventricular Dysfunction 02/2024 - 08/2006
5	Diabetes Mellitus 01/2020 - 01/2011
5	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 05/2006
5	Inflammation (Inflammations) 01/2017 - 04/2015
4	Chronic Renal Insufficiency 04/2024 - 01/2018
4	Systolic Heart Failure 01/2021 - 09/2011
3	Chronic Obstructive Pulmonary Disease (COPD) 01/2023 - 01/2021
3	Obesity 01/2023 - 01/2020
3	Heart Arrest (Cardiac Arrest) 01/2022 - 09/2014
3	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 08/2021 - 05/2011
3	Pulmonary Hypertension 01/2020 - 07/2016
3	Hyperkalemia 10/2019 - 09/2014
3	Coronary Artery Disease (Coronary Atherosclerosis) 09/2018 - 04/2015
3	Necrosis 01/2017 - 12/2005
3	Ventricular Remodeling 01/2013 - 09/2006
3	Ischemia 01/2008 - 12/2005
2	Mitral Valve Insufficiency (Mitral Regurgitation) 01/2023 - 11/2018
2	Cardiac Arrhythmias (Arrythmia) 01/2022 - 12/2005
2	Frailty 01/2022 - 01/2018
2	Bundle-Branch Block (Fascicular Block) 08/2021 - 01/2016
2	Dyspnea (Shortness of Breath) 11/2020 - 10/2019
2	Angioedema 10/2019 - 09/2014
2	Edema (Dropsy) 10/2019 - 01/2019
2	Proteinuria 01/2019 - 07/2016

Drug/Important Bio-Agent (IBA)

60	sacubitril and valsartan sodium hydrate drug combinationIBA 04/2024 - 02/2014
46	Brain Natriuretic Peptide (Natrecor)FDA Link 04/2024 - 01/2011
34	Neprilysin (Neutral Endopeptidase)IBA 01/2023 - 09/2013
31	pro-brain natriuretic peptide (1-76)IBA 04/2024 - 05/2011
27	Irbesartan FDA LinkGeneric 01/2023 - 02/2008
27	Angiotensin Receptors (Angiotensin II Receptor)IBA 01/2023 - 06/2007
26	Enalapril FDA LinkGeneric 01/2023 - 07/2014
23	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2023 - 08/2006
21	Biomarkers (Surrogate Marker)IBA 01/2023 - 12/2005
20	Natriuretic PeptidesIBA 01/2023 - 09/2011
18	paragonIBA 02/2024 - 01/2017
14	Valsartan (Vals)FDA Link 01/2023 - 06/2007
13	Matrix Metalloproteinases (MMPs)IBA 09/2014 - 01/2003
12	CollagenIBA 05/2024 - 05/2011
12	Mineralocorticoid Receptor AntagonistsIBA 08/2021 - 09/2014
11	DiureticsIBA 01/2023 - 11/2005
10	Angiotensin Receptor AntagonistsIBA 12/2021 - 06/2007
9	CreatinineIBA 04/2024 - 11/2005
9	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2006
7	aliskiren FDA Link 01/2023 - 10/2017
7	candesartanIBA 08/2021 - 01/2015
7	Fibrillar CollagensIBA 04/2015 - 01/2009
6	Peptides (Polypeptides)IBA 01/2023 - 06/2008
4	Insulin (Novolin)FDA Link 01/2023 - 03/2017
4	SodiumIBA 12/2021 - 04/2014
4	ConnectinIBA 01/2021 - 04/2015
4	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 12/2018 - 09/2013
4	Tissue Inhibitor of Metalloproteinase-1IBA 04/2015 - 01/2003
4	Peptide Hydrolases (Proteases)FDA Link 01/2013 - 05/2006
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2023 - 07/2005
3	Antihypertensive Agents (Antihypertensives)IBA 01/2021 - 06/2007
3	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA 01/2021 - 01/2019
3	Cysteine (L-Cysteine)FDA Link 01/2021 - 06/2015
3	PotassiumIBA 01/2021 - 01/2017
3	Digoxin (Digitek)FDA LinkGeneric 10/2020 - 08/2006
3	AngiotensinsIBA 10/2019 - 09/2014
3	Troponin T (Troponin T1)IBA 01/2019 - 11/2014
3	Trinitrotoluene (TNT)IBA 01/2019 - 11/2014
3	IntegrinsIBA 01/2012 - 06/2008
3	CalciumIBA 07/2011 - 12/2005
3	CalpainIBA 05/2011 - 07/2008
2	AlbuminsIBA 04/2024 - 09/2011
2	NitrogenIBA 12/2023 - 07/2016
2	Urea (Carbamide)FDA LinkGeneric 12/2023 - 07/2016
2	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 09/2023 - 01/2021
2	TroponinIBA 01/2023 - 11/2014
2	Hemoglobins (Hemoglobin)IBA 01/2023 - 01/2016
2	Guanosine Monophosphate (5' Guanylic Acid)IBA 01/2023 - 07/2016
2	AnticoagulantsIBA 11/2022 - 11/2017
2	ChloridesIBA 08/2021 - 04/2005
2	CytokinesIBA 01/2021 - 01/2020
2	Collagen Type III (Type III Collagen)IBA 01/2021 - 09/2011
2	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2021 - 07/2016
2	Galectin 3 (LGALS3)IBA 01/2021 - 01/2016
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2020 - 07/2016
2	praliciguatIBA 10/2020 - 01/2020
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019 - 01/2008

Therapy/Procedure

48	Therapeutics 04/2024 - 04/2005
4	Cardiac Resynchronization Therapy 04/2024 - 10/2015
3	Percutaneous Coronary Intervention 04/2015 - 12/2005
2	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 01/2022 - 01/2017
2	Transplantation 01/2020 - 02/2007
2	Drug Tapering 01/2019 - 01/2017